Toxicological Studies of Hydroethanolic Leaf Extract of Xylopia aethiopica (Dunal) A. Rich. (Annonaceae) on Wistar Rats

Introduction: The impact of aromatic plants used in cooking on health is indisputable.
 This study aims to evaluate the vitro cytotoxicity Artemia salina, acute and 28 days subchronic toxicity X. aethiopica dried fruit like spice Togo by oral administration extract female Wistar rats.
 Results: A. salina assay showed that hydroalcoholic presented any toxicity. LC50 values brine shrimp were 0.64 ± 0.13 mg/mL. revealed neither behavioral disturbances nor death rats. lethal dose (DL50) this greater than 5000 mg/kg body weight. results no significant change organs weight gain rats at test doses throughout treatment period. No changes haematological parameters observed apart from a increase platelet number 500 1000 mg/kg. Biochemical such as Urea, Creatinine, Triglycerides, Total cholesterol, Serum glutamic pyruvic transaminase (SGPT), C-reactive protein (CRP) glycemia not significantly changed. oxaloacetic (SGOT) Alkaline phosphatase (ALP) activities increased 500/1000 respectively. Creatine Phosphokinase (CPK) activity decrease Blood electrolytes change. histological sections organ damage.
 Conclusions: Aqueous did lead adverse effects after doses. 
 Keywords: Xylopia aethiopica, Cytotoxicity, Toxicity,